Diagnosing early-onset rheumatoid arthritis: the role of anti-CCP antibodies

Am Clin Lab. 2002 Aug-Sep;21(7):34-6.


Although the role of citrullinated peptides in the pathogenesis of RA is yet to be elucidated, their use as markers for early diagnosis and prognosis of RA seems promising. CCPs show much potential, particularly when employed in user-friendly ELISAs. All recent studies suggest an important role for citrullinated antigens in the diagnosis, prognosis, and general therapeutic management of RA. In addition to their optimal specificity, ability to distinguish between erosive and nonerosive disease, and ability to diagnose very early stage RA, they also hold promise in becoming a key serological marker for RA in the near future.

Publication types

  • Review

MeSH terms

  • Antibodies / analysis
  • Antibodies / blood*
  • Antibodies, Antinuclear / immunology
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / immunology*
  • Chemistry, Clinical / methods*
  • Citrulline / chemistry
  • Citrulline / immunology
  • Humans
  • Peptides / immunology
  • Rheumatoid Factor / immunology


  • Antibodies
  • Antibodies, Antinuclear
  • Peptides
  • antiperinuclear factor
  • Citrulline
  • Rheumatoid Factor