The mammalian endoplasmic reticulum as a sensor for cellular stress

Cell Stress Chaperones. 2002 Apr;7(2):222-9. doi: 10.1379/1466-1268(2002)007<0222:tmeraa>;2.


The recent elucidation of the mammalian unfolded protein response pathway has revealed a unique and transcriptionally complex signal transduction pathway that protects cells from a variety of physical and biochemical stresses that can occur during normal development and in disease states. Although the stress conditions are monitored in the endoplasmic reticulum, the beneficial effects of this pathway are extended to other cellular organelles and to the organism itself.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Survival / physiology
  • Endoplasmic Reticulum / chemistry
  • Endoplasmic Reticulum / physiology*
  • Environmental Exposure
  • Mice
  • Molecular Chaperones / chemistry
  • Molecular Chaperones / physiology*
  • Protein Folding
  • Signal Transduction / physiology*
  • Stress, Mechanical


  • Molecular Chaperones