[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow

Nucl Med Biol. 2002 Oct;29(7):719-27. doi: 10.1016/s0969-8051(02)00333-5.


Objectives: To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer.

Methods: Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy.

Results: MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow.

Conclusions: Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Flow Velocity
  • Breast Neoplasms / blood supply
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / physiopathology*
  • Female
  • Humans
  • Models, Biological
  • Oxygen Radioisotopes / pharmacokinetics
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics
  • Sensitivity and Specificity
  • Statistics as Topic
  • Technetium Tc 99m Sestamibi / pharmacokinetics*
  • Water / metabolism


  • Oxygen Radioisotopes
  • Radiopharmaceuticals
  • Water
  • Technetium Tc 99m Sestamibi