Goat Immune Response to Capripox Vaccine Expressing the Hemagglutinin Protein of Peste Des Petits Ruminants

Ann N Y Acad Sci. 2002 Oct;969:88-91. doi: 10.1111/j.1749-6632.2002.tb04356.x.

Abstract

Sheep-pox and capripox are contagious diseases of domestic small ruminants for which the causal agent is a poxvirus classified into the Capripoxvirus genus. Viruses of this group have a host range specific to sheep, goats, cattle, and possibly buffalo. Thus, they are clearly indicated as vectors for the development of recombinant vaccines for peste des petits ruminants (PPR). Here we report the immune response of goats inoculated with a recombinant capripox-PPR hemagglutinin.

MeSH terms

  • Animals
  • Capripoxvirus / genetics
  • Capripoxvirus / immunology*
  • Dose-Response Relationship, Immunologic
  • Genetic Vectors
  • Goat Diseases / prevention & control*
  • Goat Diseases / virology
  • Goats
  • Hemagglutinins, Viral / genetics
  • Hemagglutinins, Viral / immunology*
  • Leukocyte Count / veterinary
  • Leukocytes / immunology
  • Peste-des-Petits-Ruminants / prevention & control
  • Peste-des-Petits-Ruminants / veterinary*
  • Peste-des-petits-ruminants virus / genetics
  • Peste-des-petits-ruminants virus / immunology*
  • Poxviridae Infections / prevention & control
  • Poxviridae Infections / veterinary
  • Sheep
  • Sheep Diseases / prevention & control
  • Species Specificity
  • Vaccines, Synthetic
  • Viral Vaccines*

Substances

  • Hemagglutinins, Viral
  • Vaccines, Synthetic
  • Viral Vaccines