Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) gene

Exp Nephrol. 2002;10(5-6):374-82. doi: 10.1159/000065302.


Transforming growth factors beta (TGF-betas) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-beta(2) has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-beta(2), the renin response was investigated in mice heterozygous for a null mutation of the TGF-beta(2) gene, which had a twofold reduction in the amount of TGF-beta(2) mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-beta(2) exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arterioles / metabolism
  • Body Water / metabolism
  • Dehydration / metabolism
  • Fetus / metabolism
  • Gene Deletion*
  • Genotype
  • Heterozygote*
  • Juxtaglomerular Apparatus / metabolism
  • Kidney / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mutation / genetics
  • Mutation / physiology*
  • RNA, Messenger / metabolism
  • Renal Circulation
  • Renin / genetics
  • Renin / metabolism*
  • Transforming Growth Factor beta / genetics*
  • Transforming Growth Factor beta2
  • Water Deprivation / physiology


  • RNA, Messenger
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta2
  • Renin