CD20-mediated apoptosis: signalling through lipid rafts

Immunology. 2002 Oct;107(2):176-82. doi: 10.1046/j.1365-2567.2002.01495.x.


CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD20 / genetics
  • Antigens, CD20 / immunology*
  • Apoptosis / immunology*
  • Humans
  • Membrane Microdomains / immunology*
  • Molecular Sequence Data
  • Signal Transduction / immunology*


  • Antigens, CD20