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Review
. 2002 Aug;14(4):454-62.
doi: 10.1016/s0955-0674(02)00352-6.

Insights from yeast endosomes

Affiliations
Review

Insights from yeast endosomes

Hugh R B Pelham. Curr Opin Cell Biol. 2002 Aug.

Abstract

The endosomal system of yeast is simpler than that of animal cells, but as it is mapped more similarities are emerging. A key role for ubiquitin in sorting proteins to and into multivesicular bodies has been demonstrated. The finding that Phox homology domains recognise phosphatidylinositol 3-phosphate explains how sorting nexins are recruited to endosomes, where they mediate the retrieval of membrane proteins from the endocytic pathway.

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