Insights from yeast endosomes

Curr Opin Cell Biol. 2002 Aug;14(4):454-62. doi: 10.1016/s0955-0674(02)00352-6.

Abstract

The endosomal system of yeast is simpler than that of animal cells, but as it is mapped more similarities are emerging. A key role for ubiquitin in sorting proteins to and into multivesicular bodies has been demonstrated. The finding that Phox homology domains recognise phosphatidylinositol 3-phosphate explains how sorting nexins are recruited to endosomes, where they mediate the retrieval of membrane proteins from the endocytic pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins / metabolism
  • Clathrin / metabolism
  • Endosomes / metabolism
  • Endosomes / physiology*
  • Golgi Apparatus / metabolism
  • Intracellular Membranes / metabolism
  • Models, Biological
  • Protein Sorting Signals
  • Saccharomyces cerevisiae / metabolism*
  • Ubiquitin / metabolism
  • Vesicular Transport Proteins*

Substances

  • Carrier Proteins
  • Clathrin
  • Protein Sorting Signals
  • Ubiquitin
  • Vesicular Transport Proteins