Bactericidal Effects of Fatty Acids and Monoglycerides on Helicobacter Pylori

Int J Antimicrob Agents. 2002 Oct;20(4):258-62. doi: 10.1016/s0924-8579(02)00205-4.

Abstract

The susceptibility of Salmonella spp., Escherichia coli and Helicobacter pylori to fatty acids and monoglycerides was studied. None of the lipids showed significant antibacterial activity against Salmonella spp. and E. coli but eight of 12 lipids tested showed high activity against H. pylori, monocaprin and monolaurin being the most active. The high activity of monoglycerides against H. pylori suggests that they may be useful as active ingredients in pharmaceutical formulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Chemistry, Pharmaceutical
  • Fatty Acids, Nonesterified / pharmacology*
  • Glycerides / pharmacology*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / genetics
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Fatty Acids, Nonesterified
  • Glycerides