QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice

Immunogenetics. 2002 Oct;54(7):479-89. doi: 10.1007/s00251-002-0494-0. Epub 2002 Sep 20.


The H2-D and -Q regions of the mouse major histocompatibility complex ( Mhc or H2) have been sequenced from strain 129/SvJ (haplotype bc), revealing a D/Q region different from all other investigated haplotypes, including the closely related b haplotype. The 300-kb class I-rich region consists of the classical class I, H2-D, and 11 non-classical class I genes. The Q region was formed by two series of tandem duplications. Comparison of the segment between the D and Q1 genes with the H2-K region provides evidence that class I genes were translocated from the K region to the D region, and gives a new explanation for the weak locus specificity of the H-Kand H2-Dalleles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosomes, Artificial, Bacterial
  • Genes, MHC Class I
  • H-2 Antigens / genetics*
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Sequence Analysis, DNA


  • H-2 Antigens