[Dexamethasone enhances the effect of tropisetron and ondansetron against nausea and vomiting against nausea and vomiting after patient-controlled analgesia]

Di Yi Jun Yi Da Xue Xue Bao. 2002 Feb;22(2):159-61.
[Article in Chinese]


Objective: To study the enhancement by dexamethasone of the effect of ondansetron and tropiesetron against postoperative nausea and vomiting (PONV) in patients receiving patient-controlled analgesia (PCA) and observe the effect of dexamethasone on wound healing.

Methods: One hundred and twenty elective surgical patients receiving PCA were divided into 4 groups, including 2 control groups with the prescription of ondansetron (8 mg) and tropiesetron (3 mg) respectively (control A and B) and 2 observation groups in which the patients were given ondansetron (8 mg) plus dexamethasone (10 mg) and tropiesetron (3 mg) plus dexamethasone (10 mg) respectively (observation groups C and D). The incidence and severity of PONV was observed at 4, 8, 2, 24 h and 2, 3 d postoperatively, and the time and grade of healing of the wound evaluated.

Results: Significant difference in PONV between group A and group B was observed (P<0.01), and in the observation groups, PONV was markedly reduced compared with the control groups (C vs A, P<0.01; D vs B, P<0.05). In light of the time and grade of wound healing, the observation groups differed little from the control groups.

Conclusion: Dexamethasone (10 mg) can greatly enhance the effect of ondansetron and tropiesetron against PONV in patients receiving PCA without interfering the healing of the wound.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Analgesia, Patient-Controlled / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use*
  • Antiemetics / therapeutic use*
  • Dexamethasone / therapeutic use*
  • Drug Synergism
  • Drug Therapy, Combination
  • Humans
  • Indoles / therapeutic use
  • Nausea / drug therapy*
  • Nausea / etiology
  • Ondansetron / therapeutic use
  • Treatment Outcome
  • Tropisetron
  • Vomiting / drug therapy*
  • Vomiting / etiology
  • Wound Healing / drug effects


  • Anti-Inflammatory Agents
  • Antiemetics
  • Indoles
  • Ondansetron
  • Tropisetron
  • Dexamethasone