Light-induced helix formation

J Am Chem Soc. 2002 Oct 30;124(43):12674-5. doi: 10.1021/ja028084u.


This study shows that incorporation of [Rub2m-OH]2+ at the N-terminus of the Fs peptide enhances its stability by approximately 0.15 kcal/mol through the mechanism of dipole-dipole coupling at the excited state, suggesting that photoinduced charge generation at a well-controlled and specific location provides a convenient means to trigger helix-coil transition on nanosecond or even faster time scales.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Kinetics
  • Light
  • Oligopeptides / chemistry*
  • Organometallic Compounds / chemistry
  • Protein Folding*
  • Protein Structure, Secondary / radiation effects*
  • Ruthenium / chemistry
  • Spectrophotometry, Infrared


  • Oligopeptides
  • Organometallic Compounds
  • Ruthenium