24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate

J Clin Endocrinol Metab. 1975 May;40(5):850-5. doi: 10.1210/jcem-40-5-850.


Dehydroisoandrosterone (DHA) and cortisol were measured by radioimmunoassay and protein binding techniques respectively in plasma from blood taken at 20-min intervals over 24-h periods in 3 normal men, 2 women with Stein-Leventhal syndrome and a man with a benign adrenocortical adenoma. In all subjects but the latter, DHA and cortisol were episodic and synchronous throughout the entire day; in this patient, continuous secretion of cortisol by the tumor apparently abolished stimulation of the contralateral adrenal, and DHA production was negligible. Dehydroisoandrosterone sulfate analysis in plasma displayed a pattern which, probably because of its origin both by secretion and sulfation and its long half-life showed less synchronicity with DHA and cortisol and less fluctuation than did the free hormones.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma / blood
  • Adrenal Cortex Neoplasms / blood
  • Adult
  • Aged
  • Circadian Rhythm*
  • Dehydroepiandrosterone / blood*
  • Female
  • Humans
  • Hydrocortisone / blood*
  • Male
  • Polycystic Ovary Syndrome / blood
  • Radioimmunoassay
  • Sulfuric Acids / blood
  • Time Factors


  • Sulfuric Acids
  • Dehydroepiandrosterone
  • Hydrocortisone