Benzotrithiole 2-oxide: a new family of thiol-activated DNA-cleaving functionalities

Alex H F Lee; Albert S C Chan; Tianhu Li

doi:10.1016/s0960-894x(02)00721-7

Benzotrithiole 2-oxide: a new family of thiol-activated DNA-cleaving functionalities

Bioorg Med Chem Lett. 2002 Nov 18;12(22):3259-61. doi: 10.1016/s0960-894x(02)00721-7.

Authors

Alex H F Lee¹, Albert S C Chan, Tianhu Li

Affiliation

¹ Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

PMID: 12392727
DOI: 10.1016/s0960-894x(02)00721-7

Abstract

It was demonstrated in our studies that benzotrithiole 2-oxide was capable of causing efficient DNA cleavage in the presence of 2-mercaptoethanol or glutathione and exhibited potent cytotoxic properties against certain cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Division / drug effects
DNA / drug effects*
Drug Screening Assays, Antitumor
Glutathione
Humans
Hydrolysis / drug effects
Mercaptoethanol
Oxides / pharmacology*
Plasmids / drug effects
Sulfhydryl Compounds / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Oxides
Sulfhydryl Compounds
benzotrithiole 2-oxide
Mercaptoethanol
DNA
Glutathione