Cerebellar symptoms heralding bilirubin encephalopathy in Crigler-Najjar syndrome

Pediatr Neurol. 2002 Sep;27(3):234-6. doi: 10.1016/s0887-8994(02)00425-3.


Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-year-old female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the initial manifestation of kernicterus in children with Crigler-Najjar syndrome type I.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology
  • Cerebellar Diseases / diagnosis
  • Cerebellar Diseases / genetics*
  • Cerebellum / pathology
  • Child, Preschool
  • Crigler-Najjar Syndrome / diagnosis
  • Crigler-Najjar Syndrome / genetics*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases / diagnosis
  • Infant, Premature, Diseases / genetics*
  • Jaundice, Neonatal / diagnosis
  • Jaundice, Neonatal / genetics*
  • Kernicterus / diagnosis
  • Kernicterus / genetics*
  • Magnetic Resonance Imaging
  • Neurologic Examination