CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons

Brain Res Mol Brain Res. 2002 Oct 15;106(1-2):151-6. doi: 10.1016/s0169-328x(02)00439-4.


We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / cytology
  • Brain / metabolism
  • Expressed Sequence Tags
  • Gene Library
  • Genes, Insect / genetics
  • High Mobility Group Proteins / genetics
  • High Mobility Group Proteins / metabolism*
  • Humans
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Neurons / physiology*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Sequence Alignment
  • Tissue Distribution


  • CIC protein, human
  • Cic protein, mouse
  • High Mobility Group Proteins
  • Repressor Proteins