Effects of intranasal budesonide on symptoms, quality of life, and performance in elite athletes with allergic rhinoconjunctivitis

Clin J Sport Med. 2002 Sep;12(5):296-300. doi: 10.1097/00042752-200209000-00007.


Objective: To assess change in symptoms, quality of life (QOL), and performance ability before, during, and after treatment with budesonide in a group of Olympic and Paralympic athletes with seasonal allergic rhinoconjunctivitis (SAR/C).

Design: Because budesonide has already been proven to be an effective and well-tolerated treatment of SAR/C(1), an open-label treatment format was used.

Setting: The study was community-based with participating athletes preparing for Olympic competition.

Participants: Olympic and Paralympic athletes were screened for the presence of SAR/C using history and positive skin test results for pollen allergens.

Interventions: All were offered treatment with intranasal budesonide, applied to each nostril, once daily for eight weeks.

Outcome measurements: Symptom and medication diaries were completed before treatment and after 4 and 8 weeks of treatment. Similarly, Quality of Life (QOL) was measured with the Rhinoconjunctivitis Quality of Life Questionnaire. As a secondary outcome measure, the ability to train and compete was assessed using a performance diary.

Results: Of the 236 athletes eligible for the study, 145 (61%) agreed to participate. Forty-six percent of the athletes who were dispensed treatment did not return questionnaires. For those returning questionnaires, scores between baseline (week 0) and weeks 4 and 8 were calculated for total symptoms, QOL, and performance scores. There were statistically significant improvements in symptoms, QOL, and performance scores in athletes who used intranasal budesonide.

Conclusion: SAR/C is a common condition and has demonstrable negative effects on athletes. Better education of coaches and athletes is necessary to ensure that the condition is correctly diagnosed and treated, with safe, effective, permitted medication.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Administration, Intranasal
  • Adult
  • Air Pollution / analysis
  • Analysis of Variance
  • Australia
  • Budesonide / pharmacology
  • Budesonide / therapeutic use*
  • Conjunctivitis, Allergic / drug therapy*
  • Conjunctivitis, Allergic / physiopathology
  • Conjunctivitis, Allergic / psychology*
  • Female
  • Humans
  • Male
  • Pollen / adverse effects
  • Psychomotor Performance / drug effects*
  • Quality of Life*
  • Rhinitis, Allergic, Seasonal / drug therapy*
  • Rhinitis, Allergic, Seasonal / physiopathology
  • Rhinitis, Allergic, Seasonal / psychology*
  • Seasons
  • Severity of Illness Index
  • Sports*
  • Surveys and Questionnaires
  • Treatment Outcome


  • Budesonide