Growth slowing after acute Helicobacter pylori infection is age-dependent

J Pediatr Gastroenterol Nutr. 2002 Oct;35(4):522-6. doi: 10.1097/00005176-200210000-00012.

Abstract

Objective: Most infections occur during childhood, but the health effects of childhood infection are poorly understood. We investigated whether growth decreases in the 2 months after acute seroconversion.

Methods: We performed a nested case-control study among children 6 months to 12 years of age in a community on the outskirts of Lima, Peru. Health interviews were completed daily. Anthropometric measurements were taken monthly. Sera were collected every 4 months and tested for immunoglobulin G. Two-month height and weight gains of seroconverters were compared with gains of sex, age, and size-matched seronegative controls.

Results: In the 2 months after infection, 26 seroconverters gained a median of 24% less weight than 26 matched controls (interquartile range, 63% less to 21% more). In multivariate analysis, infection attenuated weight gain only among children aged 2 years or older. This decrease was not explained by increased diarrhea.

Conclusions: seroconversion is associated with a slowing of weight gain in children aged 2 years or older. Reasons for this finding merit additional study.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Age Factors
  • Antibodies, Bacterial / blood
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diarrhea / microbiology
  • Female
  • Growth*
  • Helicobacter Infections / blood
  • Helicobacter Infections / physiopathology*
  • Helicobacter pylori* / immunology
  • Humans
  • Immunoglobulin G / blood
  • Infant
  • Male
  • Weight Gain

Substances

  • Antibodies, Bacterial
  • Immunoglobulin G