Using a low point estimate of autocorrelation to justify analyzing single-case data with the general linear model (GLM) is questioned. Monte Carlo methods are used to examine the degree to which bias in the estimate of autocorrelation depends on the complexity of the linear model used to describe the data. A method is then illustrated for determining the range of autocorrelation parameters that could reasonably have led to the observed autocorrelation. The argument for using a GLM analysis can be strengthened when the GLM analysis functions appropriately across the range of plausible autocorrelations. For situations in which the GLM analysis does not function appropriately across this range, a method is provided for adjusting the confidence intervals to ensure adequate coverage probabilities for specified levels of autocorrelation.