Abstract
Programmed cell death (PCD) plays an important role in normal and malignant hematopoieis. In this issue of Cancer Cell, Inoue et al. (2002) demonstrate that the CED-1 homolog, Slug, is a key regulator of apoptosis in the response of early hematopoietic progenitors to gamma radiation.
MeSH terms
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Animals
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Apoptosis / physiology*
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Cell Transformation, Neoplastic
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation, Neoplastic
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Hematopoiesis / physiology*
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Hematopoiesis / radiation effects
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Hematopoietic Stem Cells / physiology
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Hematopoietic Stem Cells / radiation effects
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Humans
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Leukemia, B-Cell / genetics
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Leukemia, B-Cell / metabolism
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / metabolism
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Snail Family Transcription Factors
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Thymus Gland / radiation effects
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Transcription Factors / physiology*
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Tumor Suppressor Protein p53 / metabolism
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Zinc Fingers / physiology
Substances
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DNA-Binding Proteins
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E2a-Hlf fusion protein, human
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Oncogene Proteins, Fusion
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SNAI1 protein, human
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Snail Family Transcription Factors
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Transcription Factors
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Tumor Suppressor Protein p53