SLUGging away at cell death

Cancer Cell. 2002 Oct;2(4):249-51. doi: 10.1016/s1535-6108(02)00156-3.

Abstract

Programmed cell death (PCD) plays an important role in normal and malignant hematopoieis. In this issue of Cancer Cell, Inoue et al. (2002) demonstrate that the CED-1 homolog, Slug, is a key regulator of apoptosis in the response of early hematopoietic progenitors to gamma radiation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Neoplastic
  • Hematopoiesis / physiology*
  • Hematopoiesis / radiation effects
  • Hematopoietic Stem Cells / physiology
  • Hematopoietic Stem Cells / radiation effects
  • Humans
  • Leukemia, B-Cell / genetics
  • Leukemia, B-Cell / metabolism
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Snail Family Transcription Factors
  • Thymus Gland / radiation effects
  • Transcription Factors / physiology*
  • Tumor Suppressor Protein p53 / metabolism
  • Zinc Fingers / physiology

Substances

  • DNA-Binding Proteins
  • E2a-Hlf fusion protein, human
  • Oncogene Proteins, Fusion
  • SNAI1 protein, human
  • Snail Family Transcription Factors
  • Transcription Factors
  • Tumor Suppressor Protein p53