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. 2002 Oct 25;298(5594):789-91.
doi: 10.1126/science.1074069.

Alzheimer's Disease Is a Synaptic Failure


Alzheimer's Disease Is a Synaptic Failure

Dennis J Selkoe. Science. .


In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.

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