Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Oct 25;298(5594):799-804.
doi: 10.1126/science.1075090.

Transcriptional Regulatory Networks in Saccharomyces Cerevisiae

Free article

Transcriptional Regulatory Networks in Saccharomyces Cerevisiae

Tong Ihn Lee et al. Science. .
Free article


We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

Comment in

Similar articles

See all similar articles

Cited by 992 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources