Topical treatment of pyoderma gangraenosum

Dermatology. 2002;205(3):221-3. doi: 10.1159/000065843.


The treatment of pyoderma gangraenosum (PG) is still a therapeutic challenge. Although several drugs such as corticosteroids, dapsone, clofazimine, azathioprine, tacrolimus and cyclosporine A have been shown to be effective in this disease, side-effects of these agents limit their systemic use in seriously ill patients. In recent years, topical treatment of the disease has gained attention. Several reports show an improvement of cutaneous lesions of PG following topical treatment. These earlier reports as well as our own observations suggest that topical therapeutic regimens can be a useful and safe alternative to systemic immunosuppressive therapy in the treatment of PG. We give a review about these topically used drugs and the mechanisms probably involved.

Publication types

  • Editorial

MeSH terms

  • Administration, Cutaneous
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Betamethasone Valerate / administration & dosage
  • Betamethasone Valerate / therapeutic use*
  • Cromolyn Sodium / administration & dosage
  • Cromolyn Sodium / therapeutic use
  • Glucocorticoids
  • Humans
  • Mesalamine / administration & dosage
  • Mesalamine / therapeutic use
  • Pyoderma Gangrenosum / drug therapy*


  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Mesalamine
  • Betamethasone Valerate
  • Cromolyn Sodium