Isoniazid-resistant cavitary tuberculosis in a physician following isoniazid prophylaxis

Infect Control Hosp Epidemiol. 2002 Oct;23(10):622-5. doi: 10.1086/501983.

Abstract

Single-drug prophylaxis is recommended after tuberculin skin test conversion, but not when there is active disease on chest radiograph because resistance develops frequently. Isoniazid-resistant tuberculosis developed in a physician receiving prophylaxis despite "faint left upper lobe soft tissue density" on chest radiograph. Ignoring active disease on chest x-ray renders this strategy counterproductive and cost ineffective.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use*
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Humans
  • Infectious Disease Transmission, Patient-to-Professional
  • Isoniazid / administration & dosage
  • Isoniazid / pharmacology
  • Isoniazid / therapeutic use*
  • Male
  • Mycobacterium tuberculosis / drug effects
  • Radiography, Thoracic
  • Tuberculin Test
  • Tuberculosis, Pulmonary / diagnostic imaging*
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / prevention & control
  • Tuberculosis, Pulmonary / transmission
  • Virginia

Substances

  • Antitubercular Agents
  • Isoniazid