Biological effects of group IIA secreted phosholipase A(2)

FEBS Lett. 2002 Oct 30;531(1):7-11. doi: 10.1016/s0014-5793(02)03401-4.


Group IIA secreted phospholipase A(2) (sPLA(2)-IIA) is the most abundant element in human tissues of a large family of low molecular weight phospholipases A(2), which shows properties different from those displayed by the cytosolic phospholipase A(2) involved in the release of arachidonic acid. sPLA(2)-IIA behaves as a ligand for a group of receptors inside the C-type multilectin mannose receptor family and also interacts with heparan sulfate proteoglycans such as glypican, the dermatan/chondroitin sulfate-rich decorin, and the chondroitin sulfate-rich versican, thus being able to internalize to specific compartments within the cell and producing biological responses. This review provides a short summary of the biological actions of sPLA(2)-IIA on intracellular signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism
  • Astrocytoma / enzymology
  • Brain Neoplasms / enzymology
  • Chondroitin / metabolism
  • Flow Cytometry
  • Humans
  • Ligands
  • Models, Biological
  • Phospholipases A / metabolism
  • Phospholipases A / physiology*
  • Protein Binding
  • Signal Transduction
  • Sulfates / metabolism
  • Tumor Cells, Cultured


  • Ligands
  • Sulfates
  • Arachidonic Acid
  • Chondroitin
  • Phospholipases A