Drugs targeting the renin-angiotensin-aldosterone system

Nat Rev Drug Discov. 2002 Aug;1(8):621-36. doi: 10.1038/nrd873.


Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit or antagonize components of the renin-angiotensin-aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.

Publication types

  • Review

MeSH terms

  • Angiotensin II / antagonists & inhibitors
  • Angiotensin II / physiology
  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors / chemistry
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Animals
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Drug Delivery Systems / methods*
  • Humans
  • Receptors, Angiotensin / physiology
  • Renin-Angiotensin System / drug effects*
  • Renin-Angiotensin System / physiology*


  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Receptors, Angiotensin
  • Angiotensin II