Temporary arterial occlusion in the repair of ruptured intracranial aneurysms: an analysis of risk factors for stroke

J Neurosurg. 2002 Oct;97(4):836-42. doi: 10.3171/jns.2002.97.4.0836.


Object: This study was performed to further elucidate technical and patient-specific risk factors for perioperative stroke in patients undergoing temporary arterial occlusion during the surgical repair of their aneurysms.

Methods: One hundred twelve consecutive patients in whom temporary arterial occlusion was performed during surgical repair of an aneurysm were retrospectively analyzed. Confounding factors (inadvertent permanent vessel occlusion and retraction injury) were identified in six cases (5%) and these were excluded from further analysis. The demographics for the remaining 106 patients were analyzed with respect to age, neurological status, aneurysm characteristics, intraoperative rupture, duration of temporary occlusion, and number of occlusive episodes; end points considered were outcome at 3-month follow up and symptomatic and radiological stroke.

Conclusions: Overall 17% of patients experienced symptomatic stroke and 26% had radiological evidence of stroke attributable to temporary arterial occlusion. A longer duration of clip placement, older patient age, a poor clinical grade (Hunt and Hess Grades IV-V), early surgery, and the use of single prolonged clip placement rather than repeated shorter episodes were associated with a higher risk of stroke based on univariate analysis. Intraoperative aneurysm rupture did not affect stroke risk. On multivariate analysis, only poorer clinical grade (p = 0.001) and increasing age (p = 0.04) were significantly associated with symptomatic stroke risk.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Aneurysm, Ruptured / epidemiology*
  • Aneurysm, Ruptured / surgery*
  • Cerebral Hemorrhage / epidemiology
  • Cerebral Hemorrhage / surgery
  • Female
  • Humans
  • Intracranial Aneurysm / epidemiology*
  • Intracranial Aneurysm / surgery*
  • Intraoperative Complications / epidemiology
  • Ischemic Attack, Transient / epidemiology
  • Ischemic Attack, Transient / surgery
  • Male
  • Middle Aged
  • Prognosis
  • Reperfusion Injury / epidemiology
  • Reperfusion Injury / surgery
  • Risk Factors
  • Stroke / epidemiology*