Interaction of non-alcoholic fatty liver disease with other liver diseases

Best Pract Res Clin Gastroenterol. 2002 Oct;16(5):767-81. doi: 10.1053/bega.2002.0329.


Obesity-related steatosis is an increasingly common histological finding in liver biopsies and may co-exist with other chronic liver diseases. Although non-alcoholic fatty liver disease (NAFLD) without true steatohepatitis is generally a benign condition, when another liver disease is present, steatosis may exacerbate the liver damage. In this review, we discuss the interaction of obesity-related steatosis with chronic hepatitis C, alcoholic liver disease, disorders of hepatic iron storage and drug-induced liver disease. The role of weight reduction in minimizing liver injury in patients with chronic hepatitis C is discussed. Finally, we discuss the problems associated with orthotopic liver transplantation for patients with NAFLD.

Publication types

  • Review

MeSH terms

  • Body Mass Index
  • Chemical and Drug Induced Liver Injury*
  • Disease Progression
  • Fatty Liver / etiology*
  • Hepatitis C, Chronic / complications*
  • Hepatitis C, Chronic / genetics
  • Hepatitis, Alcoholic / complications*
  • Humans
  • Iron / metabolism
  • Liver Diseases / metabolism*
  • Liver Transplantation
  • Obesity / complications*
  • Risk Factors


  • Iron