Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer

Cancer Lett. 2002 Dec 15;188(1-2):103-7. doi: 10.1016/s0304-3835(02)00460-3.


Nuclear factor kappa-beta (NF-kappaB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-kappaB interacts with IkappaB inhibitory proteins to regulate gene expression. This study investigated common variants within the genes coding for NF-kappaB and IkappaB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Case-Control Studies
  • DNA Primers / chemistry
  • DNA, Neoplasm / analysis
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • I-kappa B Proteins / genetics*
  • NF-kappa B / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*


  • DNA Primers
  • DNA, Neoplasm
  • I-kappa B Proteins
  • NF-kappa B