Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine

Appl Radiat Isot. 2002 Dec;57(6):853-6. doi: 10.1016/s0969-8043(02)00225-7.


A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Energy Transfer
  • Fluorine / chemistry*
  • Tyrosine / chemistry*


  • Fluorine
  • Tyrosine