MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials

Neoplasia. Nov-Dec 2002;4(6):480-5. doi: 10.1038/sj.neo.7900269.

Abstract

Magnetic resonance imaging (MRI) has been utilized for screening and detecting brain tumors in mice based upon their imaging characteristics appearance and their pattern of enhancement. Imaging of these tumors reveals many similarities to those observed in humans with identical pathology. Specifically, high-grade murine gliomas have histologic characteristics of glioblastoma multiforme (GBM) with contrast enhancement after intravenous administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), implying disruption of the blood-brain barrier in these tumors. In contrast, low-grade murine oligodendrogliomas do not reveal contrast enhancement, similar to human tumors. MRI can be used to identify mice with brain neoplasms as inclusion criteria in preclinical trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology
  • Disease Models, Animal
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism
  • Gadolinium DTPA
  • Glioblastoma / diagnosis*
  • Glioblastoma / diagnostic imaging
  • Glioblastoma / pathology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Transgenic
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Radiography
  • Retroviridae / genetics
  • ras Proteins / metabolism

Substances

  • Proto-Oncogene Proteins
  • ErbB Receptors
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • ras Proteins
  • Gadolinium DTPA