The long and short of siRNAs

Mol Cell. 2002 Sep;10(3):435-7. doi: 10.1016/s1097-2765(02)00657-3.


A recent work identifies a distinct class of siRNAs derived from transgenes and endogenous retroelements in plants (Hamilton et al., 2002). This class has slower electrophoretic mobility than previously characterized siRNAs and may play an important role in transgene-induced systemic silencing and in methylation of endogenous retroelement DNA.

Publication types

  • Review

MeSH terms

  • DNA Methylation
  • Genes, Plant*
  • Genes, Reporter
  • Models, Genetic
  • RNA Interference*
  • RNA, Double-Stranded / classification
  • RNA, Double-Stranded / metabolism
  • RNA, Small Interfering / classification
  • RNA, Small Interfering / metabolism*
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Retroelements
  • Transgenes


  • RNA, Double-Stranded
  • RNA, Small Interfering
  • Recombinant Fusion Proteins
  • Retroelements