On the road to repair: PCNA encounters SUMO and ubiquitin modifications

Mol Cell. 2002 Sep;10(3):441-2. doi: 10.1016/s1097-2765(02)00653-6.


The molecular events and targets regulated by the RAD6 pathway, which mediates postreplication DNA repair, have remained elusive. Now, ubiquitin and SUMO modification of proliferating cell nuclear antigen (PCNA) is shown to be induced by DNA damage and linked to components of the RAD6 pathway.

Publication types

  • Review

MeSH terms

  • DNA Damage
  • DNA Repair
  • Genes, Fungal
  • Ligases / metabolism*
  • Proliferating Cell Nuclear Antigen / metabolism*
  • Protein Structure, Tertiary
  • SUMO-1 Protein / metabolism*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins*
  • Ubiquitin / metabolism*
  • Ubiquitin-Conjugating Enzymes


  • Proliferating Cell Nuclear Antigen
  • SUMO-1 Protein
  • Saccharomyces cerevisiae Proteins
  • Ubiquitin
  • RAD6 protein, S cerevisiae
  • Ubiquitin-Conjugating Enzymes
  • Ligases