Nogo on the go

Neuron. 2002 Oct 24;36(3):345-8. doi: 10.1016/s0896-6273(02)01018-8.

Abstract

Growth inhibition in the central nervous system (CNS) is a major barrier to axon regeneration. Recent findings indicate that three distinct myelin proteins, myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte-myelin glycoprotein (OMgp), inhibit axon growth by binding a common receptor, the Nogo66 receptor (NgR), and likely converge on a common signaling cascade.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Central Nervous System / growth & development*
  • Central Nervous System / metabolism
  • GPI-Linked Proteins
  • Humans
  • Myelin Proteins / metabolism*
  • Myelin Sheath / metabolism*
  • Myelin-Associated Glycoprotein / metabolism
  • Myelin-Oligodendrocyte Glycoprotein
  • Nerve Regeneration / physiology*
  • Nogo Proteins
  • Nogo Receptor 1
  • Receptors, Cell Surface / metabolism

Substances

  • GPI-Linked Proteins
  • MOG protein, human
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • Nogo Proteins
  • Nogo Receptor 1
  • OMG protein, human
  • RTN4 protein, human
  • RTN4R protein, human
  • Receptors, Cell Surface