Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly

Neuron. 2002 Oct 24;36(3):463-74. doi: 10.1016/s0896-6273(02)00975-3.


Three classes of neurons form synapses in the antennal lobe of Drosophila, the insect counterpart of the vertebrate olfactory bulb: olfactory receptor neurons, projection neurons, and inhibitory local interneurons. We have targeted a genetically encoded optical reporter of synaptic transmission to each of these classes of neurons and visualized population responses to natural odors. The activation of an odor-specific ensemble of olfactory receptor neurons leads to the activation of a symmetric ensemble of projection neurons across the glomerular synaptic relay. Virtually all excited glomeruli receive inhibitory input from local interneurons. The extent, odor specificity, and partly interglomerular origin of this input suggest that inhibitory circuits assemble combinatorially during odor presentations. These circuits may serve as dynamic templates that extract higher order features from afferent activity patterns.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / physiology
  • Female
  • Ganglia, Invertebrate / cytology*
  • Ganglia, Invertebrate / physiology
  • Gene Expression Regulation, Developmental / genetics
  • Genetic Markers / genetics
  • Immunohistochemistry
  • Male
  • Models, Animal
  • Nerve Net / cytology*
  • Nerve Net / physiology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neurons / cytology*
  • Neurons / physiology
  • Odorants
  • Olfactory Bulb / cytology*
  • Olfactory Bulb / physiology
  • Olfactory Pathways / cytology
  • Olfactory Pathways / physiology
  • Recombinant Fusion Proteins
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Smell / physiology*
  • Synapses / metabolism
  • Synapses / ultrastructure
  • Synaptic Transmission / physiology*


  • Drosophila Proteins
  • Genetic Markers
  • Nerve Tissue Proteins
  • Recombinant Fusion Proteins