Endocytosis: driving membranes around the bend

Cell. 2002 Oct 18;111(2):143-6. doi: 10.1016/s0092-8674(02)01044-9.


When a nascent vesicle buds, the membrane must curve. Several mechanisms have been proposed for curvature creation or stabilization. Structural analysis of the ENTH domain of the endocytic protein epsin has suggested a new mechanism, in which the ENTH domain pushes its way into membranes, thus bending them into shape.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / physiology*
  • Cell Membrane / physiology*
  • Cell Size
  • Endocytosis*
  • Models, Biological
  • Models, Molecular
  • Neuropeptides / chemistry
  • Neuropeptides / physiology*
  • Protein Structure, Tertiary / physiology
  • Vesicular Transport Proteins*


  • Adaptor Proteins, Vesicular Transport
  • Carrier Proteins
  • Neuropeptides
  • Vesicular Transport Proteins
  • epsin