Dueling activities of AIF in cell death versus survival: DNA binding and redox activity

Cell. 2002 Oct 18;111(2):147-50. doi: 10.1016/s0092-8674(02)01046-2.

Abstract

Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Apoptosis Inducing Factor
  • Cell Death*
  • Cell Survival*
  • DNA / metabolism*
  • Flavoproteins / physiology*
  • Free Radical Scavengers / metabolism
  • Humans
  • Membrane Proteins / physiology*
  • Mice
  • Models, Biological
  • Models, Molecular
  • NAD / metabolism
  • Oxidation-Reduction*
  • Oxidoreductases / physiology

Substances

  • AIFM1 protein, human
  • Apoptosis Inducing Factor
  • Flavoproteins
  • Free Radical Scavengers
  • Membrane Proteins
  • Pdcd8 protein, mouse
  • NAD
  • DNA
  • Oxidoreductases