Setting the boundaries of chromatin domains and nuclear organization

Cell. 2002 Oct 18;111(2):151-4. doi: 10.1016/s0092-8674(02)01004-8.


The nuclear architecture of the interphase nucleus is established by laying down an intricate three-dimensional framework of higher-order chromatin structure. This arrangement is essential for the integration of complex biological processes such as DNA replication, RNA processing, and transcription. Boundary or insulator elements are emerging as key players in the establishment and maintenance of this organization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / physiology*
  • Chromatin / chemistry*
  • Gene Expression Regulation
  • Humans
  • Insulator Elements / physiology*
  • Models, Molecular


  • Chromatin