A chromosome RNAissance

Cell. 2002 Oct 18;111(2):159-62. doi: 10.1016/s0092-8674(02)01039-5.


In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification.

MeSH terms

  • Animals
  • Chromosome Breakage
  • Chromosomes / physiology*
  • Gene Silencing
  • Models, Genetic
  • RNA Interference / physiology*
  • RNA, Small Interfering / physiology
  • Repetitive Sequences, Nucleic Acid
  • Schizosaccharomyces / genetics
  • Tetrahymena / genetics


  • RNA, Small Interfering