Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis

J Neurol Sci. 2002 Dec 15;205(1):83-4. doi: 10.1016/s0022-510x(02)00241-1.


We describe a patient with acute isolated bulbar palsy following enteritis. A 29-year-old man developed dysphagia and nasal voice without limb weakness, ataxia, or areflexia. High titres of serum anti-GT1a and anti-Campylobacter jejuni IgG antibodies were detected. He was treated with plasmapheresis, resulting in rapid clinical improvement. This case suggests that an acute isolated bulbar palsy may be caused by a pathology relating to Guillain-Barré syndrome (GBS), in which anti-GT1a IgG antibody may have a role.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoantibodies / analysis
  • Bulbar Palsy, Progressive / blood
  • Bulbar Palsy, Progressive / complications
  • Bulbar Palsy, Progressive / immunology*
  • Campylobacter Infections / complications
  • Campylobacter Infections / immunology*
  • Campylobacter jejuni / immunology*
  • Enteritis / complications
  • Enteritis / immunology*
  • Gangliosides / immunology*
  • Guillain-Barre Syndrome / complications
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology*
  • Male
  • Plasmapheresis


  • Autoantibodies
  • Gangliosides
  • Immunoglobulin G
  • trisialoganglioside GT1