Anti-stress and anti-fatigue effect of fermented rice bran

Phytother Res. 2002 Nov;16(7):700-2. doi: 10.1002/ptr.1019.


The anti-stress and anti-fatigue effects of a hot water extract of fermented rice bran (FRB) were investigated with Saccharomyces cerevisae IFO 2346 on rats or mice. Oral administration (1 g/kg/day) of a hot water extract of FRB inhibited major changes in weight of the adrenal, thymus, spleen and thyroid, showing the anti-stress effect. A hot water extract of FRB also inhibited the increase of GPT and LDH activity, cholesterol and serum glucose levels. Administration (1 g/kg/day) for 2 weeks significantly prolonged the swimming time, resulting in an increase of the anti-fatigue effect. From these results, it can be considered that FRB has an anti-stress and anti-fatigue effect.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Glucose / metabolism
  • Cholesterol / blood
  • Fatigue / prevention & control
  • Fermentation
  • L-Lactate Dehydrogenase / blood
  • Male
  • Mice
  • Mice, Inbred ICR
  • Organ Size
  • Oryza*
  • Physical Exertion / drug effects*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Saccharomyces cerevisiae / metabolism
  • Stress, Physiological / prevention & control
  • Swimming


  • Blood Glucose
  • Plant Extracts
  • Cholesterol
  • L-Lactate Dehydrogenase