An experimental study of therapeutic effect of ACEI on chemical-induced ARDS in rats

Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Mar;36(2):93-6.

Abstract

Objective: To investigate the role of angiotensin converting enzyme inhibitor (ACEI) in the treatment of acute respiratory distress syndrome (ARDS).

Methods: Changes in physiological and biochemical indexes, and circulating endothelial cells (CEC) were observed in rats of oleic acid-induced ARDS with ACEI-Captopril (Cap) therapy and controls, respectively.

Results: Under the normal systemic blood pressure, Captopril therapy showed good effect on ARDS in rats. Two hours after administration of Captopril, their pulmonary arterial pressure reduced to (14.43 +/- 1.51) mm Hg (1 mm Hg = 0.133 kPa), approximating to normal level, from (23.50 +/- 5.79) mm Hg. The number of CEC, which reflected injuries in pulmonary capillaries, decreased to (4.25 +/- 0.20)/0.9 micro l from (6.88 +/- 1.90)/0.9 micro l. Value of oxygen pressure in arterial blood (PaO(2)) increased to (70.48 +/- 9.54) mm Hg from (35.08 +/- 4.59) mm Hg. In the mean time, ratio of wet to dry lung weight was returned to nearly normal. So, it indicated that high-dose of oleic acid could only induce mild lung injury, and the development of ARDS was obviously inhibited by ACEI.

Conclusions: ACEI may effectively depress pulmonary arterial hypertension, block the development of ARDS, and have certain good protective effect on pulmonary capillary endothelia.

MeSH terms

  • Acute Disease
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Animals
  • Captopril / therapeutic use*
  • Disease Models, Animal
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiopathology
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / drug therapy*
  • Male
  • Oleic Acid
  • Rats
  • Rats, Wistar
  • Respiratory Distress Syndrome, Adult / chemically induced
  • Respiratory Distress Syndrome, Adult / etiology
  • Respiratory Distress Syndrome, Adult / prevention & control*

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Oleic Acid
  • Captopril