Effect of blood transfusions on cerebral haemodynamics in preterm infants

Acta Paediatr. 2002;91(9):938-41. doi: 10.1080/080352502760272623.


Aim: To assess the possible cerebral haemodynamic changes occurring in preterm infants after blood transfusions.

Methods: Preterm infants who had undergone blood transfusions were prospectively studied using both near infrared spectroscopy and cerebral Doppler ultrasonography.

Results: Fourteen infants (mean gestational age 29.6 wk, SD 2.6; mean birthweight 1,430g, SD 332) were studied at the mean age of 29 (SD 14) d. A significant increase in oxygenated haemoglobin (O2Hb), deoxygenated haemoglobin (HHb), mixed cerebral oxygen saturation (SmO2) and change in cerebral blood volume occurred after transfusion. Between ultrasound parameters, we found a decrease in diastolic velocity and an increase in resistance index.

Conclusion: Blood transfusions improve cerebral oxygen supply and induce a decrease in cerebral blood volume, probably due to an increase in cerebral vessel resistance.

Publication types

  • Comparative Study

MeSH terms

  • Anemia / diagnosis
  • Anemia / physiopathology
  • Anemia / therapy*
  • Blood Flow Velocity
  • Blood Transfusion / methods*
  • Cerebrovascular Circulation / physiology*
  • Confidence Intervals
  • Female
  • Hemodynamics / physiology*
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Intensive Care Units, Neonatal
  • Male
  • Probability
  • Prospective Studies
  • Sensitivity and Specificity
  • Spectroscopy, Near-Infrared
  • Treatment Outcome
  • Ultrasonography, Doppler