Robust estimation of the median lethal dose

J Biopharm Stat. 2002 May;12(2):137-47. doi: 10.1081/bip-120014416.


Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions. For bioassays from a pharmaceutical company, these methods extend the standard probit and logistic models, as well as the Huber's M-estimator. They are also applied to several standard examples from the literature.

MeSH terms

  • Animals
  • Biological Assay / methods
  • Biological Assay / statistics & numerical data*
  • Dose-Response Relationship, Drug
  • Lethal Dose 50
  • Mice
  • Statistics as Topic