Use of a large national database for comparative evaluation of the effect of a bronchiolitis/viral pneumonia clinical care guideline on patient outcome and resource utilization

Arch Pediatr Adolesc Med. 2002 Nov;156(11):1086-90. doi: 10.1001/archpedi.156.11.1086.


Objectives: To use a large national comparative database to measure the internal effect of a set of evidence-based bronchiolitis/viral pneumonia clinical care guidelines on clinical practice at a children's hospital, and to compare these changes with those at other children's hospitals.

Design: Prospective cohort study with retrospective and concurrent (other hospital) controls.

Setting: The Children's Hospital, Denver, Colo.

Participants: Hospitalized children with bronchiolitis and/or viral pneumonia.

Interventions: Our clinical guidelines focused on clear admission and discharge criteria, individualized transition-anticipating orders, and "prove it or don't use it" criteria for the use of respiratory syncytial virus testing, bronchodilators, chest physiotherapy, and ribavirin.

Main outcome measures: The effect of guideline implementation was determined by comparative measurement of internal changes in utilization and outcome (nosocomial infection rate) across time and by external comparison with other children's hospitals using standardized data from the Pediatric Health Information System database of the Child Health Corporation of America (Shawnee Mission, Kan).

Results: Overall, 10 636 bronchiolitis/viral pneumonia cases were studied: 1302 at the index hospital and 9334 at the 7 comparison hospitals. Internally, the index hospital's residents and attending physicians responded favorably to the bronchiolitis/viral pneumonia care guidelines, resulting in decreases in targeted resource utilization. There were no fatalities, and the number of days in the intensive care unit decreased even though the mean severity of admitted cases increased significantly. Targeted utilization was favorably affected, whereas untargeted utilization was not. Nosocomial infections did not increase with a decreased use of respiratory syncytial virus testing. The index hospital differed favorably from other children's hospitals in several categories.

Conclusion: Evidence-based care guidelines can successfully influence utilization and clinical outcome.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / therapeutic use
  • Bronchiolitis, Viral / therapy*
  • Bronchodilator Agents / therapeutic use
  • Databases as Topic*
  • Drug Utilization
  • Evidence-Based Medicine
  • Guideline Adherence
  • Humans
  • Intensive Care Units / statistics & numerical data
  • Outcome and Process Assessment, Health Care*
  • Physical Therapy Modalities / statistics & numerical data
  • Pneumonia, Viral / therapy*
  • Practice Guidelines as Topic / standards*
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / diagnosis
  • Retrospective Studies
  • Ribavirin / therapeutic use


  • Antiviral Agents
  • Bronchodilator Agents
  • Ribavirin