Immune regulation by histamine

Curr Opin Immunol. 2002 Dec;14(6):735-40. doi: 10.1016/s0952-7915(02)00395-3.


Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology
  • Antibody Formation / physiology
  • Dendritic Cells / immunology
  • Dendritic Cells / physiology
  • Histamine / immunology
  • Histamine / physiology*
  • Immune System / immunology
  • Immune System / physiology*
  • Mice
  • Monocytes / immunology
  • Monocytes / physiology
  • Receptors, Histamine / immunology
  • Receptors, Histamine / physiology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology


  • Receptors, Histamine
  • Histamine