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Review
, 6 (5), 583-9

New Reactions in Clavulanic Acid Biosynthesis

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Review

New Reactions in Clavulanic Acid Biosynthesis

Craig A Townsend. Curr Opin Chem Biol.

Abstract

Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.

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