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, 6 (5), 619-29

Glycosidase Mechanisms


Glycosidase Mechanisms

Andrea Vasella et al. Curr Opin Chem Biol.


The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism. Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

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