Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain

Brain Res Dev Brain Res. 2002 Nov 15;139(1):59-66. doi: 10.1016/s0165-3806(02)00536-9.

Abstract

We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology
  • Brain / growth & development*
  • Brain Chemistry / physiology*
  • Chlorides / metabolism
  • Epithelial Cells / metabolism
  • Female
  • Hippocampus / metabolism
  • Male
  • Pregnancy
  • RNA Probes
  • RNA, Messenger / biosynthesis*
  • Rats
  • Sodium-Potassium-Chloride Symporters / biosynthesis*
  • Solute Carrier Family 12, Member 2
  • Symporters / biosynthesis*

Substances

  • Chlorides
  • RNA Probes
  • RNA, Messenger
  • Slc12a2 protein, rat
  • Sodium-Potassium-Chloride Symporters
  • Solute Carrier Family 12, Member 2
  • Symporters
  • potassium-chloride symporters