Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC

Psychopharmacol Commun. 1975;1(3):275-83.


Racemic methadone hydrochloride was administered to male rats in daily subcutaneous injections of 10-30 mg/kg. Dependence, when assessed by naloxone challenge after 26 days, was quantitatively and qualitatively similar to that previously reported by us for rats implanted with a 75 mg morphine pellet for 72 hours. Abstinence scores in animals pretreated acutely with 10 mg/kg delta 9-THC one hour before naloxone were significantly less than those of a vehicle control group, and wet shakes and gastrointestinal signs of abstinence were blocked. These results extend previous observations of morphine abstinence attenuating properties of delta 9-THC to effects on animals dependent on methadone.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Cannabis / therapeutic use*
  • Dronabinol / therapeutic use*
  • Drug Tolerance
  • Humans
  • Male
  • Methadone*
  • Morphine Dependence / drug therapy
  • Naloxone / pharmacology
  • Phytotherapy*
  • Rats
  • Substance Withdrawal Syndrome / chemically induced
  • Substance Withdrawal Syndrome / drug therapy*
  • Substance-Related Disorders / drug therapy*


  • Naloxone
  • Dronabinol
  • Methadone